Transforming Growth Factor beta1

A subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME.

Also Known As:

TGF beta 1; TGF-beta-1; TGF-beta1 Latency-Associated Protein; TGF-beta1LAP; Transforming Growth Factor beta 1 Latency Associated Peptide; Transforming Growth Factor beta I; Latency-Associated Protein, TGF-beta1; TGF beta1 Latency Associated Protein; TGF beta1LAP; TGF-beta1; Transforming Growth Factor-beta1

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intercellular Signaling Peptides and Proteins: 29768
    - Cytokines: 164289
      - Transforming Growth Factor beta: 13953
        Transforming Growth Factor beta1: 5914
    - TGF-beta Superfamily Proteins: 1
      - Transforming Growth Factor beta: 13953
        Transforming Growth Factor beta1: 5914
- Peptides: 82426
  - Intercellular Signaling Peptides and Proteins: 29768
    - Cytokines: 164289
      - Transforming Growth Factor beta: 13953
        Transforming Growth Factor beta1: 5914
    - TGF-beta Superfamily Proteins: 1
      - Transforming Growth Factor beta: 13953
        Transforming Growth Factor beta1: 5914
Biological Factors: 2472
- Intercellular Signaling Peptides and Proteins: 29768
  - Cytokines: 164289
    - Transforming Growth Factor beta: 13953
      - Transforming Growth Factor beta1: 5914
  - TGF-beta Superfamily Proteins: 1
    - Transforming Growth Factor beta: 13953
      - Transforming Growth Factor beta1: 5914

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Disease

Drug/Important Bio-Agent (IBA)